Tongxie Yaofang Regulates Expression of NKG2DL to Enhance Anti-tumor Effect of NK Cells in Colon Cancer under Chronic Stress / 中国实验方剂学杂志

ObjectiveTo observe the effect of Tongxie Yaofang on the function of tumor-related natural killer （NK） cells under chronic stress and explore the possible molecular mechanism. MethodFifty SPF-grade BABL/C male mice were randomized into normal， model， and low-， medium-， and high-dose （6.825， 13.65， and 27.3 g·kg-1， respectively） Tongxie Yaofang groups， with 10 mice in each group. Other groups except the blank group were subjected to 7 days of chronic restraint stress， and then forced swimming and tail suspension tests were carried out to evaluate the modeling performance. After the successful modeling， rats in Tongxie Yaofang groups were administrated with low-， medium-， and high-doses of Tongxie Yaofang by gavage， while those in the other groups were administrated with normal saline by gavage. After 14 days， each group of mice was inoculated with subcutaneous colon cancer to establish the model of colon cancer under chronic stress. The pathological changes of the tumor tissue in each group of mice were observed using hematoxylin-eosin （HE） staining. The content of CD49b-positive cells in the peripheral blood and tumor tissue of mice was measured by flow cytometry. Enzyme-linked immunosorbent assay （ELISA） was employed to measure the content of molecules associated with NK cell activation in the peripheral blood. Western blot was employed to determine the protein levels of major histocompatibility complex class Ⅰ polypeptide-related sequences A and B （MICA+MICB） and UL-16-binding protein 1 （ULBP1） in the tumor tissue. ResultCompared with the normal group， the model group showed a decrease in 5-hydroxytryptamine （5-HT） content and an increase in corticosterone （CORT） content in the serum （P<0.05）. Compared with the model group， Tongxie Yaofang increased the 5-HT content and decreased the CORT content （P<0.05， P<0.01）. Compared with the normal group， the modeling increased the tumor volume and weight （P<0.05）， while Tongxie Yaofang inhibited such increases with no statistical significance. The tumor cells in the model group presented neat arrangement， irregular shape， uneven size， obvious atypia， common nuclear division， and small necrotic area， and blood vessels were abundant surrounding the tumor cells. Compared with the model group， Tongxie Yaofang groups showed sparse arrangement of tumor cells， different degrees of patchy necrosis areas in the tumor， and karyorrhexis， dissolution， and nuclear debris in the necrotic part. Compared with the normal group， the model group showed reduced CD49b-positive cells in the peripheral blood and tumor tissue （P<0.01）. Compared with the model group， Tongxie Yaofang increased CD49b-positive cells （medium dose P<0.01， high dose P<0.05， P<0.01）. Compared with the normal group， the modeling lowered the serum levels of granzymes-B （Gzms-B）， perforin （PF）， interferon （IFN）-γ， and tumor necrosis factor （TNF）-α （P<0.05， P<0.01）. Compared with the model group， low-dose Tongxie Yaofang elevated the serum levels of PF， Gzms-B， and TNF-α （P<0.05， P<0.01）， and medium-dose Tongxie Yaofang elevated the serum levels of Gzms-B， PF， IFN-γ， and TNF-α （P<0.05， P<0.01）. In addition， high-dose Tongxie Yaofang elevated the serum levels of PF， IFN-γ， and TNF-α （P<0.01）. Compared with the normal group， the model group presented down-regulated protein level of ULBP1 （P<0.05）. Compared with the model group， low-， medium-， and high-dose Tongxie Yaofang up-regulated the protein level of ULBP1 （P<0.05， P<0.01）， and medium- and high-dose Tongxie Yaofang up-regulated the protein level of MICA+MICB （P<0.05， P<0.01）. ConclusionTongxie Yaofang may promote NK cell activation by up-regulating the expression of MICA+MICB and ULBP1， thereby delaying the progression of colon cancer under chronic stress.

The characteristics of stingless bee nests (Apidae: Meliponini) in the Cycloop Mountain Nature Reserve, Indonesia

Introduction: Stingless bees are widespread in tropical and subtropical regions. In Indonesia, the distribution of stingless bees are grouped in three regions, namely Indo-Malayan, Wallacea, and Indo-Australian. Ten species of stingless bees have been recorded in Papua, seven of which are endemic. The Cycloop Mountains Nature Reserve (CMNR) is one of the conservation area in Papua, Indonesia, for flora and fauna. Unfortunately, the study of the diversity of stingless bees in Papua has been limited. Objective: To measure the diversity, nesting sites, nest entrance characteristics and nest architecture of stingless bees. Methods: Observation of the stingless bee nests in the nature reserves and in the residential areas used a road sampling method and information from local people, respectively. A total of 22 colonies were studied. Results: Two species of stingless bee were found, namely Tetragonula sapiens (Cockerell, 1911) and Heterotrigona (Platytrigona) planifrons (Smith, 1865). The current study showed new distribution records for T. sapiens and H. planifrons in the CMNR. The nesting site of T. sapiens was commonly found in house foundation, while that of H. planifrons was in coconut palm cavities. The nest entrance of T. sapiens varied, i.e., elliptical, oval, rounded, irregular, horizontally or vertically elongated. Meanwhile, the nest entrance of H. planifrons was vertically elongated. The brood cells of T. sapiens varied, i.e., vertical, horizontal, or semi-clusters, while in H. planifrons was layered vertically. Conclusions: Two species of stingless bees found, T. sapiens and H. planifrons, showed a new distribution records and T. sapiens was a dominant species in Papua. The nest entrance of the species varied in shape, color, and texture.

Introducción: Las abejas sin aguijón están muy extendidas en las regiones tropicales y subtropicales. En Indonesia, la distribución de las abejas sin aguijón se agrupa en tres regiones: Indo-Malayan, Wallacea e Indo-Australian. Se han registrado diez especies de abejas sin aguijón en Papua, siete de las cuales son endémicas. La Reserva Natural de las Montañas Cycloop (CMNR) es una de las áreas para la conservación de flora y la fauna en Papua, Indonesia. Desafortunadamente, el estudio de la diversidad de abejas sin aguijón en Papua ha sido limitado. Objetivo: Medir la diversidad, los sitios de anidación y describir la arquitectura y características de entrada al nido de las abejas sin aguijón. Métodos: Se observaron los nidos de abejas sin aguijón en reservas naturales y áreas residenciales, mediante el método de muestreo de caminos e información de la población local, respectivamente. Se estudiaron 22 colonias. Resultados: Se encontraron dos especies de abejas sin aguijón, Tetragonula sapiens (Cockerell, 1911) y Heterotrigona (Platytrigona) planifrons (Smith, 1865). Este estudio mostró nuevos registros de distribución de T. sapiens y H. planifrons en el CMNR. El sitio de anidación de T. sapiens se encontró comúnmente en los cimientos de las casas, mientras que el de H. planifrons estaba en las cavidades de las palmas de coco. La forma de la entrada al nido de T. sapiens varió: elíptica, ovalada, redondeada, irregular, alargada horizontal o verticalmente. Mientras tanto, la entrada al de H. planifrons se alarga verticalmente. Las celdas de cría de T. sapiens variaron, entre verticales, horizontales o semi-racimos, mientras que en H. planifrons eran verticales. Conclusiones: Se encontraron dos especies de abejas sin aguijón, T. sapiens y H. planifrons, que mostraron nuevos registros de distribución y T. sapiens fue una especie dominante en Papúa. La entrada al nido de las especies varió en forma, color y textura.

Study of Deliberate Self-Poisoning Among Adult Females in A Tertiary Care Hospital

Background: Poisoning is a common medico-social problem in our country causing around 300,000 episodes and around 2000 deaths per year. Attempted suicide among adult females are a major public health problem. The number of self-poisoning in females are increasing in our country day by day. The incidence, nature, etiology, age group affected and the outcome of self-poisoning in females of our country is different from that of the western world. Objective: The objective of the study was to analysis the socio-demographic profile & pattern of deliberate self-poisoning among adult females admitted in the Medicine Department, Dhaka Medical College Hospital. Material and Methods: This was a descriptive cross sectional study conducted in the Department of Medicine, Dhaka Medical College Hospital from January 2016 to June 2016. 100 admitted female participants were enrolled in this study as study population. A purposive sampling method was applied for sampling from study population. Results: The age of the participants were from 18 to 55 years with the mean age of 28.19 (± 9.84) years. Most number of the participants were in 21-29 year’s age group (42%) followed by ?20 year’s (29%). House wife (30%) was the most common occupation followed by student (25%). Most of the participants were from lower economic class (51%), followed by middle class (41%). 48% participants were in primary level, 24% in secondary level and 22% were illiterate. Most of the participants were married (51%), followed by unmarried (35%), divorced (9%) and widow (5%). 62% participants from rural and 38% from urban area. 75% were Muslim and 25% were Hindu. 55% were from the joint family and 45% were from the nuclear family. Most of the self-poisoning occurred between 6 am to 12 pm (42%), followed by 6 pm to 12 am (30%), 12 pm to 6 pm (20%) and 12 am to 6 am (8%). Insecticide was the most common poison materials (43%), followed by drug ingestion (30%), household detergent (13%), rodenticide (6%) and others (8%). Maximum participants reported the reason for self-poisoning was family disharmony (35%) followed by romantic disappointment (27%). 17% participants reported previous suicidal attempt and 11% had previous psychiatric disorder. Nearly half of the participants (43%) sought medical care within 2 hours and one fourth participants (31%) within 4 hours. About two-thirds of the participants (66%) received primary medical care from different govt. hospitals. Most of the female participants with self-poisoning were recovered completely (71%), while 20% participants recovered with complications and 9% participants died. In the study, fatality rate was found 33.3% in rodenticide and 16.3% in insecticide poisoning. Conclusions: As evident from the study, by intervene these problems by various measures might be helpful to prevent many of deliberate self-harm. Early diagnosis and prompt institution of appropriate treatment can make a favorable outcome in deliberate self-poisoning of female participants.

Effect of spirituality, exercise, music, and engagement with nature on intelligence, stress, and cognition

Background: Spirituality is recognition of a sense that there is something greater than myself. Physical exercise is any bodily activity that enhances physical fitness and overall health. Music is a universal language to express mind through tone and emotions. Nature is the physical world or the universe. Intelligence is the global capacity of the individual to act purposefully, to think rationally. Emotional intelligence is the ability to understand one’s own emotions and emotions of others. Adversity quotient deals with ability of a person to deal with adversities in life. Aims and Objectives: The present study was designed to study the effect of different interventions on intelligence, stress and cognitive functions. Materials and Methods: The present study was performed on 144 subjects in age group of 30–39 years. Their basal level of intelligence quotient (IQ), emotional quotient (EQ), resilience score (RS), acute stress score (ASS), perceived stress score (PSS), isometric handgrip (IHG), and stroop tests was recorded. The subjects were divided into four groups of 36 each. Four groups were allotted different interventions of spirituality practices, moderate intensity physical exercise, receptive music, and engagement with nature respectively for 1 month duration. Statistical analysis: ANOVA and post hoc tests along with student t-test were used for computing the results. Results: IQ, EQ, RS, ASS, IHG, PSS, and stroop subtests yielded mixed results with four interventions at different levels of significance. Conclusion: Although every intervention had different and positive impact on parameters, overall spiritual practices exhibited better response on parameters.

O percurso categorial da natureza e da história: pertinência para os estudos sobre o ser social e sua corporeidade no âmbito da Educação Física / The categorical path of nature and history: relevance for studies on the social being and its corporeality in the scope of Physical Education / El camino categórico de la naturaleza y la historia: relevancia para los estudios sobre el ser social y su corporeidad en el ámbito de la Educación Física

O presente trabalho acompanha o desenvolvimento das categorias natureza e história no pensamento filosófico-social ocidental até o século XVIII. O estudo centrado nestas categorias as entendem como importantes pressupostos para uma ontologia do ser social marxiana-lukasciana. Também entende como necessária a revisão da elaboração destes fundamentos para se compreender o corpo e a corporeidade humana constituídos no complexo relacional destas categorias. Conclui-se que a antinomia entre o natural e histórico-social neste período não possui resoluções concretas e satisfatórias para o entendimento do complexo, mas é possível observar a tentativa de cisão e superação da natureza pelo espírito racional.

This present paper follows the development of the nature and history categories in Western social-philosophical thought until the 18th century. The study focused on these categories, understanding them as important assumptions for a Marxian-Lukascian ontology of social being. It is also understood as necessary to review the elaboration of these foundations in order to understand the human body and corporeality constituted in the relational complex of these categories. It is concluded that the antinomy between the natural and the historical-social in this period does not have concrete and satisfactory resolutions for the understanding of the complex, but it is possible to observe the attempt to split and overcome nature by the rational spirit.

Este ensayo sigue el desarrollo de las categorías naturaleza e historia en el pensamiento socio-filosófico occidental hasta el siglo XVIII. El estudio centrado en estas categorías, las entiende como presupuestos importantes para una ontología del ser social presente en la obra de Marx, Engels y Lukács. Entiende también como necesaria, la revisión de la elaboración de estos fundamentos para comprender el cuerpo y la corporeidad humana constituida en el complejo relacional de estas categorías. Se concluye que la antinomia entre lo natural y lo histórico-social en este período no tiene resoluciones concretas y satisfactorias para la comprensión del complejo, pero es posible observar el intento de escisión y superación de la naturaleza por parte del espíritu racional.

Relationship between intestinal flora and location and nature of diarrheal irritable bowel syndrome in Traditional Chinese Medicine / 国际中医中药杂志

Irritable bowel syndrome is a common functional gastrointestinal disorder, among which diarrhea-type irritable bowel syndrome (IBS-D) is the main type in China, which is seriously affecting the quality of life for patients. The pathogenesis of IBS-D is still unclear. It has been found that Intestinal flora disorder is an important pathogenesis of IBS-D. There is a close relationship between intestinal flora and IBS-D TCM syndrome types, and there are differences in intestinal flora of different TCM syndrome types of IBS-D. However, TCM syndrome types are a complex and multi-factor combination. Therefore, based on the TCM theory of nature and location of disease, this article proposed the following conclusions through analyzing previous studies on intestinal flora of different TCM syndromes of IBS-D, including that the intestinal flora of different TCM syndromes have different characteristics and there are differences in the functions of flora, deficiency and excess of disease are associated with the diversity and abundance of intestinal flora, cold and heat of disease are related to the proportion of beneficial bacteria and opportunistic pathogens, and the characteristics of intestinal flora are the microcosmic manifestation of the disease position of TCM. In addition, this article also proposed the application of fecal bacteria transplantation based on the theory of nature and location of disease. Based on this theory, the study on intestinal flora of IBS-D can provide help for objectification of TCM syndrome types, and also provide TCM research ideas for revealing the pathogenesis of IBS-D.

The application law of Moutan Cortex in Synopsis of the Golden Chamber / 国际中医中药杂志

We aimed to study the articles and applied prescriptions of Moutan Cortex in Synopsis of theGolden Chamber, summarize and analyze its laws on the disease location and disease nature, and analyze its compatibility, dosage and processing laws. Based on the knowledge of Moutan Cortex by Zhongjing, we found that the kidney, bladder, uterus and intestine involved in Zhongjing's application of peony bark prescription, which belongs to the disease of "lower abdomen" in Huangdi Nei Jing. And the prescription of Moutan Cortex mainly focused on the syndromes of "depression" and "blood stasis", which are characterised by five kinds: water depression, dampness depression, stasis-heat, blood stasis and ecchymosis. and the compatibility rule of Zhongjing application of Moutan Cortex is analyzed accordingly. In addition, the study found that as the downward movement of the disease position, the amount of Moutan Cortex increased, and the processing of the problem followed the principle of "if disease is slow onset, the Moutan Cortex heart should be removed, but if disease is acute, Moutan Cortex heart should be kept". Finally, we combined modern clinical application of Moutan Cortex with modern pharmacological research, in order to expand the scope of clinical application of Moutan Cortex and "the same treatment of different diseases" to provide theoretical guidance.

Analysis of current status and risk of development in occupational medical examination institutions in Guangdong Province / 中国职业医学

Objective: To analyze the status of occupational medical examination (OME) institutions in Guangdong Province and the critical control points affecting their future development. Methods: A total of 211 OME institutions registered in Guangdong Province were selected as the research subjects. Their current statue was investigated, and the risk assessment of their future development was carried out based on hazard analysis and critical control point theory. Results: The OME institutions were mainly concentrated in the Pearl River Delta, accounting for 72.0%. The public and private medical and health institutions accounted for 70.6% and 29.4% respectively. The filing rates of different OME categories from high to low in the order were physical factors, chemical factors, dust, other, radiation factors, biological factors (P<0.01), and the filing rates were 89.6%, 88.6%, 84.8%, 63.0%, 7.1% and 1.0%, respectively. The rates of excellence in the field assessment from high to low in the order were hearing atlas analysis personnel, lung function examination operators, chest film reading personnel, chief examination physician, technical director, quality director (P<0.01), and the rates of excellence were 49.4%, 26.2%, 20.6%, 10.8%, 8.2% and 4.6%, respectively. A total of 37 institutions did not submit OME information, of which 23 institutions did not carry out OME work after filing. The required diagnosis rate and confirmed diagnosis rate of suspected occupational diseases in 2020 were 34.3% and 55.3%, respectively. In 2021, the detection rate of suspected occupational diseases was only 1.1‰. Among the institutions with biological monitoring records, 64.1% did not participate in external quality assessment program in laboratory, and the unqualified rate of 38 participating institutions was 55.3%. The risk assessment results show that the future development of OME institutions needs to focus on private institutions, institutions that have not reported OME information, institutions that have missed diagnosis and missed reporting of suspected occupational diseases, institutions that have not participated in external quality assessment program in laboratory and core personnel such as quality managers, technical leaders, and main inspection physicians. Conclusion: OME institutions in Guangdong Province show the characteristics of centralized filing category, centralized filing region and centralized filing institution nature. Combined with the potential risks of OME institutional capacity building, it is necessary to implement classified management, strengthen information construction, supervision and management, implement post responsibilities, and promote the high-quality development of OME institutions.

Nature-effect transformation mechanism of mulberry leaves and silkworm droppings based on chemical composition analysis / 中国中药杂志

Starting with the relationship between mulberry leaves and silkworm droppings as food and metabolites, this study systematically compared the chemical components, screened out differential components, and quantitatively analyzed the main differential components based on ultra-high performance liquid chromatography with quadrupole time-of-flight mass spectrometry(UPLC-Q-TOF-MS) and UPLC-Q-TRAP-MS combined with principal component analysis(PCA) and orthogonal partial least squares-discriminant analysis(OPLS-DA). Moreover, the in vitro enzymatic transformation of the representative differential components was studied. The results showed that(1) 95 components were identified from mulberry leaves and silkworm droppings, among which 27 components only exist in mulberry leaves and 8 components in silkworm droppings. The main differential components were flavonoid glycosides and chlorogenic acids.(2) Nineteen components with significant difference were quantitatively analyzed, and the components with significant differences and high content were neochlorogenic acid, chlorogenic acid, and rutin.(3) The crude protease in the mid-gut of silkworm significantly metabolized neochlorogenic acid and chlorogenic acid, which may be an important reason for the efficacy change in mulberry leaves and silkworm droppings. This study lays a scientific foundation for the development, utilization, and quality control of mulberry leaves and silkworm droppings. It provides references for clarifying the possible material basis and mechanism of the pungent-cool and dispersing nature of mulberry leaves transforming into the pungent-warm and dampness-resolving nature of silkworm droppings, and offers a new idea for the study of nature-effect transformation mechanism of traditional Chinese medicine.

"Mulher, você não precisa disso": discursos em embate sobre a pílula e a supressão da menstruação / "Woman, you don't need this": Negotiation of discourses on the pill and menstrual suppression / "Mujer, no necesitas esto": Discursos en conflicto sobre la píldora y la supresión de la menstruación

Resumo O discurso médico do século XIX listava uma série de desordens físicas e mentais associadas aos órgãos reprodutivos das mulheres (Rohden, 2009). Um fenômeno corporal até hoje frequentemente construído como patológico é a menstruação (Vieira, 2002), para o qual existe uma ferramenta médica de intervenção amplamente empregada: a pílula anticoncepcional. Como o período menstrual é muitas vezes visto como um problema, sua interrupção por meio da ingestão contínua da pílula é recorrentemente propagada como a solução (Kissling, 2013). À luz dessas ideias, analiso como duas mulheres autoidentificadas como feministas negociam significados sobre a pílula, a menstruação e a supressão menstrual em entrevistas orais semiestruturadas. O objetivo do trabalho é investigar como sentidos biomédicos sobre o corpo feminino são discursivamente reificados, desafiados e corporificados.

Abstract Nineteenth century's medical discourse listed a series of physical and mental disorders caused by women's reproductive organs (Rohden, 2009). A bodily function that until nowadays has been frequently constructed as pathological is menstruation (Vieira, 2002), for which there is a widely employed medical tool of intervention: the contraceptive pill. As the period is often seen as a problem, its suppression through the uninterrupted use of the pill is recurrently advertised as the solution (Kissling, 2013). In light of these ideas, I analyse how two self-identified feminist women negotiate meanings around the pill, menstruation and menstrual suppression in semi-structured oral interviews. The purpose of the work is to investigate how biomedical meanings of the female body are discursively reified, challenged and embodied.

Resumen El discurso médico del siglo XIX enumeraba una serie de trastornos físicos y mentales asociados a los órganos reproductivos de la mujer (Rohden, 2009). Un fenómeno corporal que con frecuencia se interpreta como patológico es la menstruación (Vieira, 2002), para la cual existe una herramienta médica intervencionista ampliamente utilizada: la píldora anticonceptiva. Como el período menstrual a menudo se ve como un problema, su interrupción a través de la toma continua de la píldora se propaga recurrentemente como la solución (Kissling, 2013). A la luz de estas ideas, analizo cómo dos mujeres autoidentificadas como feministas negocian significados sobre la píldora, la menstruación y la supresión menstrual en entrevistas orales semiestructuradas. El objetivo de este trabajo es investigar cómo los significados biomédicos sobre el cuerpo femenino son materializados, cuestionados y encarnados discursivamente.

Culturas infantis nas fotografias do parque Violeta Dória Lins (décadas de 1940 a 1960) / Children's culture in photographs of Violeta Dória Lins playground (from 1940's to 1960's) / La cultura infantil en las fotografías del parque Violeta Dória Lins (décadas 1940 a 1960)

O Parque Infantil Violeta Dória Lins foi inaugurado em 1940, em Campinas, como parte de um projeto mais amplo que tinha como finalidade educar e cuidar de crianças. Nesses parques, as intenções educativas evidenciavam o papel da arquitetura e da natureza. O objetivo deste trabalho é compreender as culturas infantis nas produções materiais e simbólicas produzidas para as crianças que frequentaram parques infantis entre as décadas de 1940 e 1960 na cidade de Campinas. Para essa investigação, foram selecionadas fotografias do acervo da instituição, bem como do Museu da Imagem e do Som de Campinas. A análise evidenciou que havia dois padrões de fotografias armazenados. Um empenhado na exibição das estruturas edificadas; outro, das práticas educativas que envolviam as crianças. Concluímos que as particularidades do projeto educacional dos Parques Infantis representavam possibilidades profícuas para a produção de culturas infantis, a partir da valorização do contato com a natureza e de um programa pedagógico voltado para atividades artísticas, trabalhos manuais, jogos e brincadeiras. (AU)

The Violeta Dória Lins Playground was inaugurated in 1940, in Campinas, as part of a larger project to educate and care for children. In these parks, the educational intentions highlighted the role of architecture and nature. This paper aims to understand children's cultures in the material and symbolic productions produced for the children who frequented playgrounds between the 1940s and 1960s in Campinas. For this investigation, photographs were selected from the institution's collection and the Museum of Image and Sound of Campinas. The analysis showed that there were two patterns of stored photographs, one committed to the display of the built structures, the other to the educational practices involving children. We conclude that the particularities of the educational project of the Playgrounds represented fruitful possibilities for the production of children's cultures, from the appreciation of the contact with nature and a pedagogical program focused on artistic activities, crafts, games, and play. (AU)

El Parque Infantil Violeta Dória Lins fue inaugurado en 1940, en Campinas, como parte de un proyecto más amplio destinado a la educación y el cuidado de los niños. En estos parques, las intenciones educativas estaban vinculadas a la arquitectura y la naturaleza. El objetivo de este trabajo es comprender las culturas infantiles en las producciones materiales y simbólicas producidas para los niños que asistían a los parques infantiles entre las décadas de 1940 y 1960 en la ciudad de Campinas. Las fotografías fueron seleccionadas de la colección de la institución, así como del Museu da Imagem e do Som. El análisis mostró que había dos corrientes de fotografías, una comprometida con la exhibición de las estructuras construidas y la otra, con las prácticas educativas. Concluimos que las particularidades del proyecto educativo de los Parques Infantiles representaron posibilidades fructíferas para la producción de culturas infantiles, a partir de la valoración del contacto con la naturaleza y en un programa pedagógico centrado en actividades artísticas, trabajos manuales, juegos y actividades lúdicas. (AU)

Embracing the cordillera: Luis Carranza Ayarza and the development of environmental imaginaries in late-nineteenth-century Peru / Abrazando la cordillera: Luis Carranza Ayarza y el desarrollo de los imaginarios ambientales en el Perú de fines del siglo XIX

Abstract This article examines the relationship between local scientific ideas about the natural world and the economic potential to transform the modern nation-state in Peru during the late nineteenth century. Writings by the Peruvian scientist Luis Carranza indicate how support for a distinctive environmental imaginary of the country's geography made it possible to conceptualize nature as an essential component of Peruvian identity. As a result, local scientists had to "imaginatively" reshape the nature of the Andes for modernization purposes. The social and political ramifications of these ideas in Carranza's work were key to the foundation of scientific institutions such as the Geographical Society of Lima.

Resumen Este artículo examina la relación entre las ideas científicas locales sobre el mundo natural y el potencial económico para transformar el Estado-nación moderno en el Perú a fines del siglo XIX. Los escritos del científico peruano Luis Carranza señalan cómo el apoyo a un imaginario ambiental distintivo de la geografía del país permitió conceptualizar la naturaleza como componente esencial de la identidad peruana. Como resultado, los científicos locales tuvieron que remodelar "imaginativamente" la naturaleza de los Andes con fines de modernización. Las ramificaciones sociales y políticas de estas ideas en la obra de Carranza fueron clave para la fundación de instituciones científicas como la Sociedad Geográfica de Lima.

Educación ambiental en tiempos de crisis socio-ambiental: posibilidades de su inclusión en la formación de terapia ocupacional, desde la perspectiva de las/os docentes / Educação ambiental em tempos de crise socioambiental: possibilidades de sua inclusão na formação em terapia ocupacional, desde a perspectiva de docentes / Environmental education in times of social-environmental crisis: possibilities of its inclusion in occupational therapy training, from the academics' perspective

Resumen Introducción La crisis socio-ambiental es un tema relevante y existe una urgencia en su reflexión y búsqueda de soluciones en todas las áreas del conocimiento. Este estudio, usando como base la educación ambiental, se hace parte de dicha necesidad desde la formación profesional en terapia ocupacional. Objetivo Analizar las posibles relaciones entre la educación ambiental y la formación disciplinar, a partir de la perspectiva de los y las terapeutas ocupacionales que se dedican a la docencia universitaria en la provincia de Concepción, Chile. Método Metodología cualitativa con la realización de 7 entrevistas individuales a terapeutas ocupacionales que se desempeñan como docentes universitarios. La información se somete a un análisis de contenido temático y triangulación teórica. Resultados Existen fundamentos teóricos y éticos en la disciplina vinculados a la naturaleza, que pueden ser incluidos en la formación profesional. Se plantea que esta temática debe ser abordada de manera transversal en la formación. Las metodologías de enseñanza más acordes para su implementación serían de carácter teórico práctico como el aprendizaje basado en proyectos o el aprendizaje de servicio. Las acciones basadas en la naturaleza pueden ser enseñadas como una estrategia de intervención al servicio del cuidado de la naturaleza, y al mismo tiempo para el cuidado de las personas y comunidades. Conclusiones Se invita a incluir la educación ambiental en la formación de terapeutas ocupacionales, dado que es una herramienta potente para avanzar en la protección y conservación el medio ambiente.

Resumo Introdução A crise socioambiental é um tema relevante e há urgência em sua reflexão e busca de soluções em todas as áreas do conhecimento. Este estudo, tendo como base a educação ambiental, torna-se parte dessa necessidade de formação profissional em terapia ocupacional. Objetivo Analisar as possíveis relações entre educação ambiental e formação disciplinar, desde a perspectiva de terapeutas ocupacionais que se dedicam ao ensino universitário na província de Concepción, Chile. Método Metodologia qualitativa, com a realização de sete entrevistas individuais com terapeutas ocupacionais que atuam como professores universitários. A informação é submetida a uma análise de conteúdo temática e triangulação teórica. Resultados Existem fundamentos teóricos e éticos nas disciplinas ligadas à natureza, que podem ser incluídos na formação profissional. Propõe-se que esta temática seja abordada de forma transversal na formação. As metodologias de ensino mais adequadas para a sua implementação seriam de natureza teórico-prática, como a aprendizagem baseada em projetos ou a aprendizagem em serviço. As ações baseadas na natureza podem ser ensinadas como uma estratégia de intervenção ao serviço do cuidado da natureza e, ao mesmo tempo, do cuidado das pessoas e das comunidades. Conclusão Convida-se a incluir a educação ambiental na formação de terapeutas ocupacionais, pois é uma ferramenta poderosa para avançar na proteção e conservação do meio ambiente.

Abstract Introduction The socio-environmental crisis is a relevant issue and there is an urgency in its reflection and search for solutions in all areas of knowledge. This study, using environmental education as a base, becomes part of this need from professional training in occupational therapy. Objective To analyze the possible relationships between environmental education and disciplinary training, from the perspective of occupational therapists who are dedicated to university teaching in the province of Concepción, Chile. Method Qualitative methodology through 7 individual interviews with occupational therapists who work as university academics. The information is subjected to a thematic content analysis and theoretical triangulation. Results There are theoretical and ethical foundations in the discipline linked to nature, which can be included in professional training. It is proposed that this issue should be addressed transversally in training. The most appropriate teaching methodologies for its implementation would be of a theoretical-practical nature, such as project-based learning or service learning. Nature-based actions can be taught as an intervention strategy at the service of caring for nature, and at the same time for caring for people and communities. Conclusions It is invited to include environmental education in the training of occupational therapists, since it is a powerful tool to advance in the protection and conservation of the environment.

Ethical Controversy and Reflection on Gene Enhancement / 中国医学伦理学

Gene enhancement is one of the research hotspots at home and abroad in recent years. Gene enhancement is expected to treat human genetic diseases and improve human abilities and traits, but it also raises a series of ethical problems. From the perspective of ethics, those who support gene enhancement, starting from the open and unfinished state of human nature, advocate that gene enhancement is an effective alternative to promote human nature for kindness and social equity, and believe that gene enhancement does not necessarily lead to inequality, on the contrary, it contributes to moral improvement. Opponents, starting from the integrity of human nature, hold that gene enhancement challenges human dignity, causes a crisis of human identity, has a serious impact on social fairness and justice, and is also a violation of the natural order. By sorting out and analyzing the ethical viewpoints that support and oppose gene enhancement, this paper found that the social fairness and justice issues caused by gene enhancement can be reasonably solved through exercising the roles of the government and the market, while the human nature problems caused by gene enhancement are more complex, and the setting of natural standards lacks a basis. At the same time, gene enhancement also makes people further reflect on the relationship between human and technology.

On Socrates’ Health Ethics Thought / 中国医学伦理学

Socrates understood the significance of health and disease to humans from the dimensions of body and soul, and advocated that humans should live a life consistent with nature. Socrates’ virtue of temperance, which is most closely related to health, emphasizes that self-control is the foundation of training a healthy body and mind, and having temperance is the premise for constructing healthy city-state. Faced with the problems of unhealthy lifestyle, infinite expansion of consuming desires, and materialization of interpersonal relations in modern society, Socrates’ health ethics thought has certain practical significance in transforming medical model and reconstructing positive health concept.

The Construction of Doctor-patient Community with a Shared Future Based on Mencius’ Theory of Original Goodness of Human Nature / 中国医学伦理学

Since the first medical reform, China has carried out three reforms and improvements to the medical system. However, there are still some shortcomings, the problems at different levels are mainly reflected in the doctor-patient relationship. Doctor-patient conflict has become one of the hot topics of social focus. Under the development of the country and the joint efforts of all parties, doctor-patient conflict has been alleviated to a certain extent, and the doctor-patient relationship has been developing in a better direction. With the proposal of the concept of "doctor-patient community with a shared future", the joint construction of a community between doctors and patients has become a further goal. Mencius’ theory of original goodness of human nature echoes the construction of the contemporary doctor-patient community with a shared future. It criticizes the empirical theory of human nature and emphasizes the constructive and initiative of goodness in nature, that is, to achieve goodness in nature through preservation and expansion. In the doctor-patient relationship, goodness in nature is the construction of doctor-patient community with a shared future, which requires both doctors and patients to work together with firm confidence and gradually complete the construction of the community by continuous practice.

Time to treat the climate and nature crisis as one indivisible Global Health Emergency

@#Over 200 health journals call on the United Nations, political leaders, and health professionals to recognise that climate change and biodiversity loss are one indivisible crisis and must be tackled together to preserve health and avoid catastrophe. This overall environmental crisis is now so severe as to be a global health emergency.

On the brink: The climate and nature crisis and risks of nuclear war

@#The Russian military invasion of Ukraine on February 24, 2022, and Hamas’ terror attack on Israel on October 7, 2023, signaled the beginning of two of the most recent wars to make international headlines. To date, over 110 armed conflicts are taking place: over 45 in the Middle East and North Africa (Cyprus, Egypt, Iraq, Israel, Libya, Morocco, Palestine, Syria, Turkey, Yemen, Western Sahara); over 35 in Africa (Burkina Faso, Cameroon, the Central African Republic, the Democratic Republic of the Congo, Ethiopia, Mali, Mozambique, Nigeria, Senegal, Somalia, South Sudan, Sudan); 21 in Asia (Afghanistan, India, Myanmar, Pakistan, the Philippines); seven in Europe (Russia, Ukraine, Moldova, Georgia, Armenia, Azerbaijan); and six in Latin America (three each in Mexico and Colombia); with two more international armed conflicts (between India and Pakistan, and between India and China) in Asia.1 This list does not even include such problematic situations as those involving China and the South East Asia region. As though these situations of armed violence were not enough, mankind has already passed or is on the verge of passing several climate tipping points – a recent review lists nine Global core tipping elements (and their tipping points) - the Greenland Ice Sheet (collapse); West Antarctic Ice Sheet (collapse); Labrador-Irminger Seas / SPG Convection (collapse); East Antarctic Subglacial Basins (collapse); Amazon Rainforest (dieback); Boreal Permafrost (collapse); Atlantic M.O. Circulation (collapse); Arctic Winter Sea Ice (collapse); and East Antarctic Ice Sheet (collapse); and seven Regional impact tipping elements (and their tipping points) – Low-latitude Coral Reefs (die-off); Boreal Permafrost (abrupt thaw); Barents Sea Ice (abrupt loss); Mountain Glaciers (loss); Sahel and W. African Monsoon (greening); Boreal Forest (southern dieback); and Boreal Forest (northern expansion).2 Closer to home, how can we forget the disaster and devastation wrought by Super Typhoon Haiyan (Yolanda) 10 years ago to date? Whether international or non-international, armed conflicts raise the risk of nuclear war. Russia has already “rehearsed its ability to deliver a ‘massive’ nuclear strike,” conducting “practical launches of ballistic and cruise missiles,” and stationed a first batch of tactical nuclear weapons in Belarus,3 and the possibility of nuclear escalation in Ukraine cannot be overestimated.4 Meanwhile, in a rare public announcement, the U.S. Central Command revealed that an Ohio- class submarine (560 feet long, 18,750 tons submerged and carrying as many as 154 Tomahawk cruise missiles) had arrived in the Middle East on November 5, 2023.5 Indeed, “the danger is great and growing,” as “any use of nuclear weapons would be catastrophic for humanity.”

Development of a nature posture treatment suspension therapy based on ICF-CY / 中国康复理论与实践

ObjectiveTo develop a rehabilitation program of nature posture treatment (NPT) suspension therapy based on the International Classification of Functioning, Disability and Health-Children and Youth version (ICF-CY) framework, and apply it to neurodevelopmental disorders. MethodsThe ICF-CY theoretical group (group A) and NPT suspension therapy group (group B) were established. Group A searched literature from common databases, to extract high-frequency words related to suspension therapy and match with categories of ICF-CY, to develop ICF-CY theoretical framework of the NPT suspension therapy. Group B developed specific rehabilitation procedures and training items based on the framework to compose the training pool. A total of 110 children aged less than six years with neurodevelopmental disorders and associated motor impairments were selected from outpatient or inpatient of the First Affiliated Hospital of Xinxiang Medical University, between October, 2019 and October, 2022. They were randomly divided into control group (n = 55) and clinical group (n = 55), who received routine neurodevelopmental therapy and NPT suspension therapy program based on ICF-CY, respectively, for a week. The incidence of satisfaction, acceptance and adverse events were observed. ResultsTwo cases in the control group and four cases in the clinical group dropped down. For the clinical group, the incidence of satisfaction was 98% (50/51), with acceptance of 96% (49/51), and one adverse event occurred. For the control group, the incidence of both the satisfaction and acceptance was 100%, and no adverse event occurred. There was no significant difference in the incidence of satisfaction, acceptance and the adverse event (P > 0.05). ConclusionThe NPT suspension therapy program based on the ICF-CY framework is safe and acceptable for children with neurodevelopmental disorders.

Cardiovascular Comorbidity and its Impact on Patients with COVID-19 in a Tertiary Care Hospital, Bangladesh

Background: People with cardiovascular issues have been shown to be at an elevated risk of acquiring the 2019 new corona virus infection, according to studies (COVID-19). This study’s objective was to determine if cardiovascular disease has any effect on the severity of COVID-19.Material & Methods:Between January 2020 and December 2020, 210 comorbid patients aged over 40 years old diagnosed with COVID-19 admitted in BIRDEM hospital in Bangladesh were recruited purposively for a cross sectional study as per inclusion criteria. A baseline study was created for each patient based on their medical history, physical examination, biochemical tests, and the amount of care they needed (intensive care vs. ward-based care). SPSS 26 was used to analyze the data.Results:Among the 210 comorbid individuals, 74 had cardiovascular comorbidities and the remaining 136 had other comorbidities. Among the respondents, 48% were serious cases and required ICU support within 30 days. Cases with up to 2 comorbidities did not require ICU support. The severity of COVID-19 was predicted by factors such as age above 80 years (OR 35.5, 95 percent CIs 18.7,98.5), male gender (OR 3.14, CI 1.16, 3.50), and a high troponin level in the patient’s blood (OR 1.34, CI 0.84,3.54). It was shown that cardiovascular comorbidities (CI=1.8,3.0) were 2.9 times more likely to be linked to severity. The risk factors also included a history of diabetes, hypertension, and chronic obstructive pulmonary disease. Conclusions:Cardiovascular patients, who were previously grouped together as high risk due to the nature of their ailment, need more tailored counseling and treatment from public health authorities and clinicians.